C,diff. is a spore-forming bacterium. C. difficile is a major cause of antibiotic associated diarrhoea and colitis, healthcare associated infections (HCAI’s) that mostly affect elderly patients with other underlying diseases.
Certain antibiotics may change the natural balance of bacteria in the bowel; this enables C.diff to multiply and produce toxins that can cause diarrhoea. C. diff acquisition may result in asymptomatic carriage, loose stools or profuse diarrhoea which can result in life-threatening pseudo-membranous colitis and toxic megacolon. CDI is most common in people over the age of 65 years but any age group may be susceptible, with the exception of very young children (<2yrs).
