Pneumococcal infections are classified as invasive or non-invasive depending on the site affected and include; bronchitis, otitis media, acute sinusitis and conjunctivitis amongst others, and are also one of the leading causes of pneumonia. The elderly, young children (particularly neonates), and people who are immunocompromised are the most susceptible.
Invasive Pneumococcal Diseases (IPD) are pneumococcal infections of sterile sites, such as blood, cerebrospinal fluid (CSF) caused by S. pneumoniae. They are a major cause of morbidity and mortality, especially in the very young, elderly and people who are immunocompromised.
Pneumococcal meningitis is a type of IPD and one of the most frequently reported causes of meningitis. Signs and symptoms include headache, fever, nausea and vomiting, stiffness of the neck and photophobia.